In a Nov. 5 research announcement, UT Southwestern described a multi-immersion oblique plane microscope, or miOPM, reported in Nature Methods. The light-sheet platform can switch among oil-, water- and air-immersion objectives; an adjustable zoom element helps maintain imaging performance as the immersion environment changes. The team demonstrated imaging of live cells, tissue and multiwell plates on research systems. It is a laboratory platform, not an approved clinical diagnostic instrument.
GLOBAL IMAGING BRIEF
Analysis: Accommodating different objectives within one light-sheet platform may simplify experiments across specimen scales. Laboratories should compare resolution, field of view, phototoxicity and changeover time for each immersion mode; the announcement does not quantify cost savings.
Original source
Original source: UT Southwestern Medical Center research release dated Nov. 5, describing work in Nature Methods. Clinical use and quantified cost savings are not established.